Game Predictions | Bills vs. Cardinals

Worth seeing storyline of the Cardinals: Sunday will be the highly anticipated debut date of Cardinals rookie WR Marvin Harrison Jr., and there will be a lot to watch. How will he be used by Cardinals offensive coordinator Drew Petzing and QB Kyler Murray? How will the Bills have him play? How will he handle his first NFL game? People around him are raving about his maturity and how his NFL learning curve has been shortened because of that maturity and his family background. — Josh Weinfuss

Bill’s storyline to watch: It will be interesting to see exactly what this Bills offense looks like in Week 1. The wide receiver room went through big changes this offseason, with Joe Brady taking over the role of offensive coordinator full-time. The now-healthy first-team offense saw limited playing time in the preseason, with eight snaps for QB Josh Allen. This will be the first meaningful game the group gets. It will be a good opportunity for Allen and the offense to start the year at home against a Cardinals defense that allowed the second-most points per game in 2023 (26.8). — Alaina Getzenberg

Worth knowing: With the departure of Stefon Diggs (Houston) and Gabe Davis (Jacksonville), the Bills lost 45% of their receiving yards and 52% of their receiving touchdowns from last season.

Bold prediction: Bills wide receiver Khalil Shakir will catch seven or more balls. Rookie Keon Coleman could one day become the team’s No. 1 receiver, but Shakir is probably the most reliable wide receiver right now, especially after he posted a strong 2.1 yards per carry last season. I’m confident he’ll do some damage against a weak Cardinals defense. — Walder

Fantasy X-Factor: Bills running back James Cook. The Cardinals had the league’s worst run defense last season, ranking 32nd in rushing yards allowed per game (143.2). With minimal offseason additions, Arizona’s defensive front remains vulnerable, setting the stage for a standout performance from Cook. In Weeks 11-18 last season, he averaged 19.6 touches and 16.4 fantasy points per game. See Week 1 rankings. — Moody

Betting Nugget: Murray is 12-7-1 ATS in his career when he scores at least four points, including 10-4-1 ATS on the road. Read more.

Kahler’s choice: Cardinals 21, Bills 20

Moody’s selection: Bills 31, Cardinals 24

Walder’s choice: Bills 33, Cardinals 17

FPI forecast: BUF, 67.7% (average 7.3 points)